| Expression pattern: |
UN |
| Associated gene: |
TNF-a, IL-1b, MCP-1, PI3K, Akt, mTOR |
| Associated microRNA: |
- |
| Biological function: |
circUBAP2 correlates with improved microcirculatory perfusion and better outcomes, inhibits macrophage migration, promotes M2 polarization, and suppresses inflammatory cytokine production. |
| Molecular mechanism: |
circUBAP2 suppresses inflammatory behavior in macrophages by inhibiting cytokine production and the PI3K/Akt/mTOR signaling pathway. |
| Biological pathway or process: |
migration (inhibits); macrophage polarization (promotes); inflammation (inhibits); PI3K/AKT/mTOR (inhibits); immune regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; Survival Analysis; ROC Analysis |
| Clinical significance: |
circUBAP2 correlates with microcirculatory perfusion and predicts 30-day in-hospital mortality; higher circUBAP2 expression is associated with better prognosis and lower risk of in-hospital death. |
| Description: |
In cardiogenic shock patients receiving V-A ECMO, higher blood circUBAP2 expression is associated with improved microcirculatory perfusion, better 30-day survival, and lower in-hospital mortality risk. Functionally, circUBAP2 suppresses macrophage migration and inflammatory cytokine production, promotes M2 polarization, and inhibits the PI3K/Akt/mTOR pathway. |
| Confidence score: |
0.6527 |