circRNA basic information
circBase ID: hsa_circ_0006758
Name: hsa_circ_UCK2
Synonym: hsa_circRNA_100375
Host Gene: UCK2
Genomic location(hg19): chr1:165859440-165860559:+
Genomic location(hg38): chr1:165890203-165891322:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007576
MONDO name: esophageal cancer
Disease details: esophageal cancer
Disease DO ID:
 5041
Disease MeSH ID:
 -
Disease NCIt ID:
 C7478
Disease ICD11 ID:
 669033105
Disease OMIM ID:
 133239
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissues; adjacent normal tissue; tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: UCK2, FGFR1, PTGER2, WNT9B, WNT2B, SP1, CREBBP, IL-6, DVL2
Associated microRNA: hsa-miR-324-3p, hsa-miR-29a-5p, hsa-miR-485-3p, hsa-miR-149-5p
Biological function: Up-regulated in EC tumor tissues; involved in a predicted cancer-related circRNA-miRNA axis and may be a key gene regulating EC tumorigenesis and a potential biomarker or therapeutic target.
Molecular mechanism: Predicted cancer-related circRNA-miRNA-mRNA/protein-associated pathway involving hsa-miR-324-3p, hsa-miR-29a-5p, hsa-miR-485-3p, and hsa-miR-149-5p, with hub proteins including FGFR1, PTGER2, WNT9B, WNT2B, SP1, CREBBP, IL-6, and DVL2.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other); proliferation (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May be a potential biomarker and therapeutic target for EC treatment.
Description:

hsa_circRNA_100375 is an up-regulated exonic circRNA in EC tumor tissues and was experimentally validated by RT-PCR. The study predicts that it participates in a cancer-related circRNA-miRNA axis with hsa-miR-324-3p, hsa-miR-29a-5p, hsa-miR-485-3p, and hsa-miR-149-5p, with downstream pathway-associated proteins including FGFR1, PTGER2, WNT9B, WNT2B, SP1, CREBBP, IL-6, and DVL2, suggesting potential biomarker and therapeutic target value.
Confidence score:

0.5135
Other information
Title:

A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.

Journal: Journal of gastrointestinal oncology
Published: 2022
PubMed ID: 35557573
Study type:

combined biological and clinical study
Data availability: GSE103104
Code availability: -