circRNA basic information
circBase ID: hsa_circ_0004585
Name: hsa_circ_KIAA1199
Synonym: -
Host Gene: KIAA1199
Genomic location(hg19): chr15:81166204-81212640:+
Genomic location(hg38): chr15:80873863-80920299:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent normal tissues; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-299-3p, hsa-miR-431-5p, hsa-miR-4657, hsa-miR-4691-5p, hsa-miR-15b-5p, hsa-miR-3912-5p, hsa-miR-424-5p, hsa-miR-497-5p, hsa-miR-6736-3p, hsa-miR-6778-3p, hsa-miR-6801-5p, hsa-miR-6838-5p, hsa-miR-1262, hsa-miR-23a-5p, hsa-miR-23b-5p, hsa-miR-4701-3p, hsa-miR-4709-3p, hsa-miR-4764-5p, hsa-miR-4769-3p, hsa-miR-5695
Biological function: May contribute to CRC carcinogenesis and metastasis; potential diagnostic biomarker.
Molecular mechanism: Predicted to act as a miRNA sponge via miRNA binding sites; downstream mechanism not experimentally validated.
Biological pathway or process:

metastasis (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Higher diagnostic accuracy by ROC analysis in CRC tissues (AUC 0.731) and peripheral samples (AUC 0.707); positively correlated with tumor size; potential diagnostic marker for CRC.
Description:

hsa_circ_0004585 is up-regulated in CRC tissues and in patients’ peripheral blood and shows diagnostic potential by ROC analysis. It is derived from KIAA1199 and is predicted (bioinformatically) to bind multiple miRNAs, but its downstream mechanism in CRC remains unclear.
Confidence score:

0.5047
Other information
Title:

CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer.

Journal: Cancer management and research
Published: 2019
PubMed ID: 31354349
Study type:

combined biological and clinical study
Data availability: -
Code availability: -