| Expression pattern: |
UP |
| Associated gene: |
TMBIM6, mTOR, CCNB1, Ago2, MMP9, MMP2, HK2, caspase3, ki-67 |
| Associated microRNA: |
miR-526b-3p |
| Biological function: |
Hsa_circ_0001495 promotes cervical cancer cell glycolysis, proliferation, invasion, migration and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Hsa_circ_0001495 acts as a miR-526b-3p sponge to positively regulate TMBIM6 expression and activate mTOR phosphorylation/signaling in cervical cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); EMT (promotes); PI3K/AKT/mTOR (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; ELISA; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Hsa_circ_0001495 acted as a potential diagnosis marker and could be a potential marker for CC diagnosis and prognosis. |
| Description: |
Hsa_circ_0001495 is up-regulated in cervical cancer tissues and cell lines. It promotes glycolysis, proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, mainly by sponging miR-526b-3p to regulate TMBIM6 and mTOR phosphorylation. The study proposes hsa_circ_0001495 as a potential diagnostic/prognostic marker and therapeutic target in cervical cancer. |
| Confidence score: |
0.8299 |