| Expression pattern: |
UP |
| Associated gene: |
CEP55, centrosomal protein 55, Bcl-2, Bax |
| Associated microRNA: |
miR-130a-3p |
| Biological function: |
Promotes RCC tumor growth, cell proliferation, angiogenesis, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circSDHC functions as a miR-130a-3p sponge to increase CEP55 expression, thereby promoting malignant phenotypes and angiogenesis in RCC. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); angiogenesis (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Tube Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circSDHC expression was associated with AJCC stage_T and STAGE in RCC patients. |
| Description: |
circSDHC is up-regulated in RCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes RCC tumor growth, proliferation, angiogenesis, migration and invasion while suppressing apoptosis. Mechanistically, circSDHC acts as a miR-130a-3p sponge to increase CEP55 expression, supporting the circSDHC/miR-130a-3p/CEP55 regulatory axis as a potential therapeutic target in RCC. |
| Confidence score: |
0.7373 |