| Expression pattern: |
DN |
| Associated gene: |
SFRP2 |
| Associated microRNA: |
miR-629-5p |
| Biological function: |
Circ_0059961 acts as a tumor suppressor in cholangiocarcinoma, inhibiting tumor cell proliferation, migration, invasion, EMT-related changes and in vivo tumor growth while promoting apoptosis. |
| Molecular mechanism: |
Circ_0059961 functions through a ceRNA mechanism by sponging miR-629-5p and thereby increasing SFRP2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Low circ_0059961 expression was associated with advanced TNM stage, lymph node invasion and poor survival; circ_0059961 could be used as a biomarker for cholangiocarcinoma. |
| Description: |
Circ_0059961 is down-regulated in cholangiocarcinoma tissues and cells and functions as a tumor-suppressive circRNA. Its overexpression suppresses proliferation, migration, invasion, EMT-associated changes and xenograft tumor growth while promoting apoptosis, mainly through the circ_0059961/miR-629-5p/SFRP2 ceRNA axis. Clinically, low circ_0059961 expression is associated with advanced TNM stage, lymph node invasion and worse overall survival. |
| Confidence score: |
0.7887 |