circRNA basic information
circBase ID: hsa_circ_0032279
Name: -
Synonym: circ0032279
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human osteosarcoma tissues; related normal bone tissues
Cell lines:

MG63; MG-63; OB3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SND1
Associated microRNA: -
Biological function: circ0032279 was down-regulated in osteosarcoma, but no significant SND1-associated pull-down change and no functional role were demonstrated.
Molecular mechanism: No validated molecular mechanism was established for circ0032279; it was screened as a potential SND1-binding osteosarcoma-related circRNA but did not show significant RIP pull-down changes with SND1 manipulation.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Clinical Sample Validation
Clinical significance:

-
Description:

circ0032279 was identified as a down-regulated circRNA in osteosarcoma by RT-PCR validation after screening. Unlike circ0024831, it did not show significant SND1-associated RIP pull-down changes, and the study did not establish a functional or mechanistic role for circ0032279 in osteosarcoma.
Confidence score:

0.4685
Other information
Title:

Mechanism for Bioactive Nanomaterial circ0024831 Regulation of Staphylococcal Nuclease Domain Containing 1 via RNA Methylation Recognition in Osteosarcoma.

Journal: Journal of biomedical nanotechnology
Published: 2022
PubMed ID: 35484754
Study type:

combined biological and clinical study
Data availability: -
Code availability: -