circRNA basic information
circBase ID: hsa_circ_0012634
Name: hsa_circ_TMEM59
Synonym: circTMEM59
Host Gene: TMEM59
Genomic location(hg19): chr1:54506428-54509198:-
Genomic location(hg38): chr1:54040755-54043525:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent normal tissues
Cell lines:

SW480; SW620; LOVO; HCT116; HCoEpiC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: HOXD8
Associated microRNA: miR-410-3p
Biological function: Inhibits CRC cell proliferation, migration, invasion, metastasis and tumor growth.
Molecular mechanism: circTMEM59 acts as a miR-410-3p sponge and positively regulates HOXD8 to suppress CRC progression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

circTMEM59 was lower in tissues from CRC patients with higher tumor stage and might be a potential target for CRC treatment.
Description:

circTMEM59 (hsa_circ_0012634), derived from TMEM59, is down-regulated in CRC tissues and cells. It functions as a tumor suppressor by sponging miR-410-3p to increase HOXD8 expression, thereby inhibiting CRC proliferation, migration, invasion, metastasis and xenograft tumor growth. Its reduced expression is associated with higher tumor stage, suggesting potential therapeutic relevance.
Confidence score:

0.7944
Other information
Title:

CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8.

Journal: Biochemical genetics
Published: 2022
PubMed ID: 35426617
Study type:

combined biological and clinical study
Data availability: GSE142837; https://doi.org/10.1007/s10528-022-10224-5; data sets generated during the study are available from the corresponding author on reasonable request
Code availability: -