circRNA basic information
circBase ID: -
Name: hsa_circ_CDYL
Synonym: circ-chromodomain Y-like
Host Gene: CDYL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018876
MONDO name: mantle cell lymphoma
Disease details: mantle cell lymphoma
Disease DO ID:
 0050746
Disease MeSH ID:
 D020522
Disease NCIt ID:
 C4337
Disease ICD11 ID:
 1804127841
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

Z138; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MALAT1, NEAT1, EBLN3P, NORAD, XIST, NOTCH1, FMR1, ABCB1, TWIST1, VEGFA
Associated microRNA: hsa-miR-129-5p, hsa-miR-3163, hsa-miR-4662a-5p, hsa-miR-101-3p, hsa-miR-186-5p
Biological function: promotes MCL cell proliferation
Molecular mechanism: Bioinformatics-predicted circCDYL-miRNA-mRNA-lncRNA co-expression/ceRNA network
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); MAPK (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; CCK8; Bioinformatics Analysis
Clinical significance:

circCDYL had diagnostic value in distinguishing MCL patients from healthy controls (AUC = 0.856)
Description:

circCDYL is up-regulated in the plasma of mantle cell lymphoma patients and shows diagnostic potential (AUC 0.856). Functionally, circCDYL promotes proliferation of MCL Z138 cells, since circCDYL knockdown suppresses proliferation. The proposed mechanism is a bioinformatically predicted circCDYL-miRNA-mRNA/lncRNA regulatory network involving five highlighted miRNAs and targets including NOTCH1, ABCB1, TWIST1 and VEGFA.
Confidence score:

0.6422
Other information
Title:

CircCDYL Serves as a New Biomarker in Mantle Cell Lymphoma and Promotes Cell Proliferation.

Journal: Cancer management and research
Published: 2019
PubMed ID: 31819653
Study type:

combined biological and clinical study
Data availability: -
Code availability: -