circRNA basic information
circBase ID: hsa_circ_0051620
Name: hsa_circ_SLC1A5
Synonym: circ_0051620
Host Gene: SLC1A5
Genomic location(hg19): chr19:47278139-47280662:-
Genomic location(hg38): chr19:46774882-46777405:-
Subcellular localization: unclear
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004950
MONDO name: gastric carcinoma
Disease details: gastric cancer / GC
Disease DO ID:
 10538, 5517
Disease MeSH ID:
 -
Disease NCIt ID:
 C4911
Disease ICD11 ID:
 1503707183
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; tumoral tissues; non-cancerous groups; normal control samples
Cell lines:

AGS; HGC27; MKN-45; MKN74; GES-1; MKN45
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ADAM17
Associated microRNA: miR-338-3p
Biological function: Promotes gastric cancer cell proliferation, tumor growth, migration, invasion, progression and metastasis; knockdown inhibits GC cell growth, migration and invasion.
Molecular mechanism: circ_0051620 acts as a sponge for miR-338-3p and upregulates ADAM17 expression, thereby promoting gastric cancer progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
M
Validation methods:

RNase R Treatment; RT-qPCR; RNA-seq; Microarray; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Overexpression is associated with progress, poor prognosis and TNM stage in gastric cancer.
Description:

circ_0051620 is up-regulated in gastric cancer tissues and cell lines and its high expression is associated with TNM stage and poor prognosis. Functionally, circ_0051620 promotes GC cell proliferation, migration and invasion by sponging miR-338-3p and increasing ADAM17 expression, suggesting the circ_0051620/miR-338-3p/ADAM17 axis as a potential therapeutic target.
Confidence score:

0.7566
Other information
Title:

Circular RNA circ_0051620 sponges miR-338-3p and regulates ADAM17 to promote the gastric cancer progression.

Journal: Pathology, research and practice
Published: 2022
PubMed ID: 35413598
Study type:

combined biological and clinical study
Data availability: GSE83521; The data is available from the corresponding author upon reasonable request.
Code availability: -