| Expression pattern: |
UP |
| Associated gene: |
DDX58, IFIH1 |
| Associated microRNA: |
hsa-miR-105-5p, hsa-miR-128-3p, hsa-miR-140-5p, hsa-miR-141-5p, hsa-miR-197-3p, hsa-miR-203a-5p |
| Biological function: |
Exclusive to viremic patients; proposed to participate in competing endogenous networks potentially influencing viral replication. |
| Molecular mechanism: |
Predicted MRE/miRNA sequestration in circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); viral replication (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
CircRNA candidate exclusive to viremic patients and undetectable after ART, proposed as viremia-associated biomarker/target candidate. |
| Description: |
circANKRD17 (hsa-ANKRD17_0008) was detected in all viremic (pre-ART) patients and became undetectable in post-ART patients. It was included in predicted circRNA-miRNA-mRNA competing networks (with several predicted miRNA response elements) that may influence HIV-1-related host/viral post-transcriptional regulation. |
| Confidence score: |
0.1768 |