circRNA basic information
circBase ID: -
Name: hsa_circ_TMCO3
Synonym: circTMCO3
Host Gene: TMCO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

GES-1; MKN28; SGC-7901; KATO III; HGC-27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RAB14
Associated microRNA: miR-577
Biological function: promotes proliferation, migration and invasion of gastric cancer cells
Molecular mechanism: acts as a miRNA sponge for miR-577, thereby regulating RAB14
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down
Clinical significance:

-
Description:

circTMCO3 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration, and invasion. Mechanistically, it sponges miR-577 to de-repress the miR-577 target RAB14, forming a circTMCO3/miR-577/RAB14 axis that drives oncogenic phenotypes.
Confidence score:

0.7369
Other information
Title:

CircTMCO3 Promotes Gastric Cancer Progression by Regulating miR-577/RAB14 Axis.

Journal: Cancer management and research
Published: 2021
PubMed ID: 34377026
Study type:

combined biological and clinical study
Data availability: -
Code availability: -