| Expression pattern: |
UP |
| Associated gene: |
APLN |
| Associated microRNA: |
hsa-miR-124-5p |
| Biological function: |
Potential diagnostic biomarker for CRC (high diagnostic efficiency by ROC); suggested involvement in CRC pathogenesis. |
| Molecular mechanism: |
Predicted ceRNA network (cirReNET): circRNA sponging miRNAs to regulate target mRNAs; predicted core axis hsa_circRNA_100833-hsa-miR-124-5p-APLN. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic marker for CRC (ROC AUC = 0.6860). |
| Description: |
hsa_circRNA_100833 (host gene FADS2) is up-regulated in CRC tumor tissues versus adjacent normal tissues and shows diagnostic value by ROC analysis. The study predicts it may act in a circRNA-miRNA-mRNA ceRNA network, with a proposed core axis hsa_circRNA_100833-hsa-miR-124-5p-APLN, but the mechanism is not experimentally validated. |
| Confidence score: |
0.5963 |