| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-199a |
| Biological function: |
Serum circMTO1 assists diagnosis of cervical cancer and HR-HPV-positive cervical cancer; elevated circMTO1 is associated with clinical stage, tumor differentiation, lymph node metastasis, invasion depth, and higher risk of HR-HPV infection. |
| Molecular mechanism: |
circMTO1 potentially functions as a ceRNA by sponging miR-199a in HR-HPV-positive cervical cancer. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Serum circMTO1 has diagnostic value for cervical cancer and HR-HPV infection in cervical cancer; high expression is associated with clinical stage, tumor differentiation, lymph node metastasis, invasion depth, and independently linked with HR-HPV infection. |
| Description: |
This study found that serum circMTO1 is upregulated in cervical cancer and further elevated in HR-HPV-positive cervical cancer. Its serum level showed diagnostic value for CC and HR-HPV-positive CC and was associated with adverse clinicopathological features and higher HR-HPV infection risk. Mechanistically, circMTO1 was predicted and experimentally validated to bind miR-199a, suggesting a potential circMTO1/miR-199a ceRNA relationship in HR-HPV-positive CC. |
| Confidence score: |
0.559 |