| Expression pattern: |
DS |
| Associated gene: |
PDGFD |
| Associated microRNA: |
miR-429 |
| Biological function: |
Regulates gastric cancer progression and immune microenvironment by modulating an immune-gene signature via the circ-0007707/miR-429/PDGFD pathway. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) to absorb miR-429 and regulate PDGFD expression. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection |
| Clinical significance: |
- |
| Description: |
circ-0007707 is implicated in gastric cancer as a ceRNA that sponges miR-429, thereby increasing PDGFD expression. This axis is proposed to influence gastric cancer progression by modulating the tumor immune microenvironment and an immune-gene signature. |
| Confidence score: |
0.3213 |