| Expression pattern: |
DN |
| Associated gene: |
KDM6A |
| Associated microRNA: |
miR-26-5p |
| Biological function: |
circLDLR inhibits VSMC proliferation and promotes VSMC apoptosis in the CAD-related vascular smooth muscle cell context. |
| Molecular mechanism: |
circLDLR modulates the miR-26-5p/KDM6A axis; overexpression of circLDLR decreases miR-26-5p, increases KDM6A expression, inhibits VSMC proliferation, and promotes apoptosis. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circLDLR is down-regulated in CAD tissues and may be a promising target for CAD therapy. |
| Description: |
circLDLR is significantly down-regulated in CAD tissues. Functionally, circLDLR overexpression suppresses VSMC proliferation and promotes apoptosis, at least partly through modulation of the miR-26-5p/KDM6A axis, suggesting therapeutic relevance for CAD. |
| Confidence score: |
0.6479 |