circRNA basic information
circBase ID: -
Name: hsa_circ_RAD18
Synonym: circRNA_002453 / hsa_circRNA_002453
Host Gene: RAD18
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005556
MONDO name: lupus nephritis
Disease details: lupus nephritis / LN
Disease DO ID:
 0080162
Disease MeSH ID:
 D008181
Disease NCIt ID:
 C34789
Disease ICD11 ID:
 1815692673
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential noninvasive diagnostic biomarker for lupus nephritis and biomarker of severity of renal involvement; positively correlated with 24-hour proteinuria and renal SLEDAI score.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Upregulated plasma circRNA_002453 is associated with severity of renal involvement in LN and has diagnostic value with AUC 0.906, sensitivity 0.900, and specificity 0.841 for discriminating LN patients from controls.
Description:

Plasma circRNA_002453 is significantly upregulated in lupus nephritis and also elevated in SLE compared with RA patients and healthy controls. Its level correlates positively with renal involvement indicators and shows strong diagnostic performance for LN, supporting its role as a potential noninvasive biomarker rather than a functionally characterized mechanistic regulator.
Confidence score:

0.5662
Other information
Title:

Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis.

Journal: Molecular immunology
Published: 2018
PubMed ID: 30172209
Study type:

clinical biomarker study
Data availability: Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.molimm.2018.07.029.
Code availability: -