circRNA basic information
circBase ID: hsa_circ_0003570
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:126370175-126384781:-
Genomic location(hg38): chr10:124681606-124696212:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002407
MONDO name: capillary hemangioma
Disease details: infantile hemangioma / IH
Disease DO ID:
 2725
Disease MeSH ID:
 D018324
Disease NCIt ID:
 C7457
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HEMECs; HDMVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RGS5
Associated microRNA: hsa-miR-138-5p
Biological function: Promotes proliferation, migration and invasion and inhibits apoptosis of hemangioma endothelial cells (HEMECs) in infantile hemangioma.
Molecular mechanism: Acts as a ceRNA (miRNA sponge) for hsa-miR-138-5p to upregulate RGS5.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

In infantile hemangioma endothelial cells, hsa_circ_0003570 is upregulated and promotes malignant behaviors (proliferation/migration/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging hsa-miR-138-5p to increase RGS5 expression.
Confidence score:

0.5979
Other information
Title:

GEO Database Screening Combined with In Vitro Experiments to Study the Mechanism of hsa_circ_0003570 in Infantile Hemangiomas.

Journal: Computational and mathematical methods in medicine
Published: 2022
PubMed ID: 35529258
Study type:

combined biological and bioinformatics study
Data availability: GSE98795; GSE100682; GSE43742
Code availability: -