| Expression pattern: |
UP |
| Associated gene: |
DDX5 |
| Associated microRNA: |
miR-362-3p |
| Biological function: |
circDHDDS promotes TNBC cell proliferation, migration, invasion, angiogenesis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circDHDDS functions as a ceRNA by binding miR-362-3p, thereby relieving miR-362-3p-mediated suppression of DDX5 and promoting TNBC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circDHDDS expression was associated with tumor size, lymph node metastasis and TNM stage in patients with TNBC. |
| Description: |
circDHDDS is up-regulated in TNBC tissues and cells and acts as a tumor-promoting circRNA. Mechanistically, it binds miR-362-3p to increase DDX5 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. |
| Confidence score: |
0.8443 |