| Expression pattern: |
UP |
| Associated gene: |
FUS, DGCR8 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation and migration, and suppresses apoptosis of vascular smooth muscle cells |
| Molecular mechanism: |
Bioinformatics prediction suggests it may act as a miRNA sponge (circRNA-miRNA-mRNA network) and may encode a PKC_like super family domain; knockdown reduces OPN, YAP1, MMP2 and MMP9 protein levels. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); MAPK (other); NF-kappaB (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; FISH / smFISH; Bioinformatics Analysis; Transfection; MTT; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Wound Healing Assay |
| Clinical significance: |
- |
| Description: |
hsa_circ_0005505 is up-regulated in ruptured intracranial aneurysm tissues versus un-ruptured tissues and promotes HBVSMC proliferation and migration while inhibiting apoptosis. It is mainly localized in the cytoplasm and is associated with predicted circRNA-miRNA-mRNA interactions and potential protein-coding capacity; knockdown decreases OPN, YAP1, MMP2 and MMP9 levels. |
| Confidence score: |
0.697 |