| Expression pattern: |
UP |
| Associated gene: |
C•caspase•3, p21, cyclin D1 |
| Associated microRNA: |
miR•153 |
| Biological function: |
circZNF609 may act as an oncogenic factor in diffuse large B-cell lymphoma; down-regulation of circZNF609 inhibits OCI•LY19 cell proliferation, arrests the cell cycle, and induces apoptosis. |
| Molecular mechanism: |
circZNF609 targets miR•153; knockdown of circZNF609 increases miR•153 expression and affects apoptosis- and proliferation-related proteins C•caspase•3, p21, and cyclin D1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circZNF609 may be a potential target for targeted gene therapy of diffuse large B-cell lymphoma. |
| Description: |
circZNF609 is up-regulated in diffuse large B-cell lymphoma tissues. Functional knockdown experiments in OCI•LY19 cells indicate that circZNF609 promotes proliferation and cell-cycle progression and suppresses apoptosis, at least partly by targeting miR•153 and modulating C•caspase•3, p21, and cyclin D1. |
| Confidence score: |
0.6521 |