circRNA basic information
circBase ID: hsa_circ_0001785
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr8:28013458-28019595:+
Genomic location(hg38): chr8:28155941-28162078:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CEA, CA15-3
Associated microRNA: -
Biological function: acts as a diagnostic biomarker for breast cancer detection; associated with histological grade, TNM stage and distant metastasis
Molecular mechanism: -
Biological pathway or process:

metastasis (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0001785 had diagnostic value for breast cancer detection, with AUC values of 0.771 in the validation cohort and 0.784 in larger samples; its expression was related to histological grade, TNM stage and distant metastasis.
Description:

hsa_circ_0001785 is up-regulated in plasma from breast cancer patients and was validated by RT-qPCR after microarray screening. It showed diagnostic value for breast cancer detection and was associated with histological grade, TNM stage and distant metastasis.
Confidence score:

0.5662
Other information
Title:

Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.

Journal: Clinica chimica acta; international journal of clinical chemistry
Published: 2018
PubMed ID: 29045858
Study type:

combined biological and clinical study
Data availability: -
Code availability: -