| Expression pattern: |
DN |
| Associated gene: |
DAB2IP, E-cadherin, Vimentin, Snail |
| Associated microRNA: |
miR-556-3p, miR-435-3p, miR-635, miR-671-5p, miR-1208 |
| Biological function: |
Inhibits HCC cell growth, migration and invasion, and promotes apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-556-3p to regulate DAB2IP and thereby modulate EMT-related proteins. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation |
| Clinical significance: |
Low circSLCO1B7 expression is associated with TNM stage, lymph node metastasis and tumor size; circSLCO1B7 is decreased in plasma of HCC patients compared with healthy controls, suggesting potential diagnostic value. |
| Description: |
circSLCO1B7 is down-regulated in HCC tissues and patient plasma and functions as a tumor suppressor. It mainly localizes in the cytoplasm and inhibits proliferation, migration/invasion and EMT while promoting apoptosis by sponging miR-556-3p to upregulate DAB2IP. |
| Confidence score: |
0.868 |