circRNA basic information
circBase ID: hsa_circ_0001974
Name: hsa_circ_TKT
Synonym: hsa_circTKT_008
Host Gene: TKT
Genomic location(hg19): chr3:53267171-53269190:-
Genomic location(hg38): chr3:53233155-53235174:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011122
MONDO name: obesity disorder
Disease details: obesity
Disease DO ID:
 9970
Disease MeSH ID:
 -
Disease NCIt ID:
 C3283
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

subcutaneous adipose tissue (SATs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-668-3p, hsa-miR-194-3p, hsa-miR-182-5p, hsa-miR-588, hsa-miR-494-5p
Biological function: might induce/promote adipogenesis
Molecular mechanism: predicted ceRNA mechanism via inhibiting miRNAs (miR-194; miR-182)
Biological pathway or process:

ceRNA regulation (other); proliferation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0001974 (host gene TKT) is significantly up-regulated during SAT-derived hADSC differentiation into adipocytes and its back-splice junction was verified. The study proposes a miRNA-related mechanism, suggesting it may induce adipogenesis by inhibiting miR-194 and/or miR-182 (based on predicted circRNA-miRNA-mRNA network).
Confidence score:

0.5135
Other information
Title:

Expression Analysis of circRNAs in Human Adipogenesis.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy
Published: 2024
PubMed ID: 38192493
Study type:

combined biological and clinical study
Data availability: -
Code availability: -