| Expression pattern: |
UP |
| Associated gene: |
monocyte chemoattractant protein-1 (MCP-1) |
| Associated microRNA: |
miRNA-124a |
| Biological function: |
CircHIPK3 may act as a key player in RA pathogenesis, promoting joint inflammation and disease severity by increasing MCP-1 production through miRNA-124a sequestration. |
| Molecular mechanism: |
CircHIPK3 functions as a miRNA sponge that sequesters miRNA-124a, which is associated with increased MCP-1 production and inflammatory biomarkers in RA. |
| Biological pathway or process: |
inflammation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ELISA |
| Clinical significance: |
CircHIPK3 may be involved in RA pathogenesis and disease severity and may represent a therapeutic target together with miRNA-124a and downstream adaptor molecules. |
| Description: |
This study found that circHIPK3 is significantly up-regulated in serum from RA patients across all disease activity grades. The authors propose that circHIPK3 contributes to RA pathogenesis and severity by sponging miRNA-124a, thereby associating with increased MCP-1 production and joint inflammation. circHIPK3/miRNA-124a crosstalk is suggested as a potential therapeutic target in RA. |
| Confidence score: |
0.4128 |