| Expression pattern: |
UP |
| Associated gene: |
SPIN1 |
| Associated microRNA: |
miR-485-3p |
| Biological function: |
promotes BC cell proliferation, migration, invasion, angiopoiesis, and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0000129 acts as a miR-485-3p sponge to upregulate SPIN1 expression, thereby promoting BC progression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0000129 was overexpressed in BC specimens compared with paired normal specimens |
| Description: |
hsa_circ_0000129/circ_0000129 is up-regulated in breast cancer tissues and cell lines. It promotes malignant breast cancer phenotypes, including proliferation, migration, invasion, angiopoiesis, and xenograft tumor growth, while suppressing apoptosis. Mechanistically, it localizes mainly in the cytoplasm and acts as a miR-485-3p sponge to relieve miR-485-3p-mediated repression of SPIN1. |
| Confidence score: |
0.8512 |