circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: hsa_circNRIP1_007
Host Gene: NRIP1
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential non-invasive diagnostic biomarker for colorectal cancer risk assessment and early detection
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0004771 showed diagnostic potential for distinguishing CRC patients from healthy controls, with AUC of 0.784, sensitivity of 84%, and specificity of 64%; combined with hsa_circ_0019120, AUC was 0.8348 with sensitivity of 84% and specificity of 80%.
Description:

Platelet-derived hsa_circ_0004771 was upregulated in CRC and advanced polyp patients, with statistically significant upregulation in CRC compared with healthy controls. The study supports its potential clinical utility as a non-invasive biomarker for CRC risk assessment and early detection, especially when combined with hsa_circ_0019120.
Confidence score:

0.4187
Other information
Title:

Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps.

Journal: Reports of biochemistry & molecular biology
Published: 2024
PubMed ID: 40330565
Study type:

clinical study
Data availability: -
Code availability: -