circRNA basic information
circBase ID: hsa_circ_0031242
Name: hsa_circ_PRMT5
Synonym: circPRMT5
Host Gene: PRMT5
Genomic location(hg19): chr14:23389732-23392044:-
Genomic location(hg38): chr14:22920523-22922835:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tumor tissues; paracancer tissues; serum
Cell lines:

MCF-10A; T47D; MCF-7; BT549; Hs-578T; MDA-MB-231; MDA-MB-468
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes breast cancer cell proliferation, invasion, and migration; associated with aggressive clinicopathologic features and poor prognosis.
Molecular mechanism: Not investigated in this study; authors cite a prior report of a miR-509-3p/TCF7L2 axis activating PI3K/AKT.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

High circPRMT5 expression correlates with poor prognosis; ROC curve suggests diagnostic potential (AUC > 0.8).
Description:

circPRMT5 is upregulated in breast cancer tissues, patient serum, and breast cancer cell lines. Functionally, circPRMT5 promotes proliferation, migration and invasion in vitro, and higher circPRMT5 expression is associated with worse patient survival and diagnostic potential by ROC analysis.
Confidence score:

0.6579
Other information
Title:

Circular RNA circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration.

Journal: Turkish journal of medical sciences
Published: 2022
PubMed ID: 36161608
Study type:

combined biological and clinical study
Data availability: -
Code availability: -