| Expression pattern: |
UP |
| Associated gene: |
YAP1, PDZD8, c-Myc, Bcl-2, E-cadherin, Ki67 |
| Associated microRNA: |
miR-520h |
| Biological function: |
Promotes gefitinib chemoresistance, tumor growth, cell proliferation, migration and invasion, while inhibiting apoptosis and supporting cell cycle progression in gefitinib-resistant NSCLC. |
| Molecular mechanism: |
circ_0091537 acts as a competing endogenous RNA that competitively decoys miR-520h to increase YAP1 expression, thereby promoting gefitinib resistance and malignant phenotypes in NSCLC. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0091537 may be a key indicator in resistance to treatment of NSCLC. |
| Description: |
circ_0091537 is up-regulated in gefitinib-resistant NSCLC cells and tumor samples. It promotes gefitinib chemoresistance and malignant behaviors by sponging miR-520h to increase YAP1 expression. Knockdown of circ_0091537 reduces IC50, suppresses proliferation, migration, invasion, and tumor growth, and enhances apoptosis and gefitinib sensitivity. |
| Confidence score: |
0.8175 |