| Expression pattern: |
UP |
| Associated gene: |
BACE1 |
| Associated microRNA: |
miR-328 |
| Biological function: |
circ-AXL promotes neuron injury and neuroinflammation in cellular AD models, increasing apoptosis and inflammatory cytokines while decreasing neurite outgrowth. |
| Molecular mechanism: |
circ-AXL directly binds miR-328 and increases BACE1 expression through targeting miR-328, forming a circ-AXL/miR-328/BACE1 regulatory axis. |
| Biological pathway or process: |
apoptosis (promotes); inflammation (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Transfection; TUNEL; ELISA; Western Blot; Luciferase Reporter Assay; Microarray |
| Clinical significance: |
circ-AXL was previously reported to be closely related to higher AD risk and elevated AD severity; this study suggests it may serve as a potential treatment target in AD. |
| Description: |
circ-AXL is up-regulated in amyloid beta-induced cellular AD models. It aggravates neuronal injury and neuroinflammation by sponging miR-328 and thereby increasing BACE1 expression, leading to increased apoptosis and inflammatory cytokines and reduced neurite outgrowth. The circ-AXL/miR-328/BACE1 axis is proposed as a potential therapeutic target in Alzheimer's disease. |
| Confidence score: |
0.6436 |