| Expression pattern: |
UP |
| Associated gene: |
CXCR4, AGO2 |
| Associated microRNA: |
miR-381-3p |
| Biological function: |
promotes proliferation, migration, invasion, immune evasion, and resistance to anti-PD-1 therapy in NSCLC |
| Molecular mechanism: |
circFGFR1 acts as a miRNA sponge for miR-381-3p to upregulate CXCR4 expression, promoting NSCLC progression and anti-PD-1 resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); immune regulation (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; RIP (RNA Immunoprecipitation); circRIP; Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
circFGFR1 expression is associated with deleterious clinicopathological characteristics and poor prognoses for NSCLC patients; circFGFR1 expression is an independent predictor for postoperative recurrence and overall survival |
| Description: |
circFGFR1 is up-regulated in NSCLC tissues and promotes proliferation, migration/invasion, metastasis-related phenotypes, and immune evasion. It functions as a ceRNA by sponging miR-381-3p to increase CXCR4 expression, contributing to resistance to anti-PD-1 therapy and poorer patient prognosis. |
| Confidence score: |
0.8168 |