circRNA basic information
circBase ID: hsa_circ_0000375
Name: hsa_circ_IFFO1
Synonym: -
Host Gene: IFFO1
Genomic location(hg19): chr12:6657590-6657991:-
Genomic location(hg38): chr12:6548424-6548825:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissue
Cell lines:

SW480
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TPM2, SRPX, SRGAP1
Associated microRNA: miR-424-5p, miR-761
Biological function: promotes migration (liver metastasis-related phenotype)
Molecular mechanism: ceRNA network involving miR-424-5p to regulate TPM2, SRPX and SRGAP1
Biological pathway or process:

migration (promotes); metastasis (promotes); EMT (other); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay
Clinical significance:

-
Description:

hsa_circ_0000375 is down-regulated in CRC tissues with liver metastasis versus without metastasis and is proposed to act in a ceRNA network by sponging miR-424-5p to modulate TPM2, SRPX and SRGAP1. Functionally, reducing hsa_circ_0000375 decreases CRC cell migration, and the effect is partially reversible via miR-424-5p inhibition.
Confidence score:

0.5623
Other information
Title:

In silico whole-transcriptome analysis reveals a potential hsa_circ_0000375-miR-424-5p-TPM2/SRPX/SRGAP1 regulatory network related to liver metastasis of colorectal cancer.

Journal: Heliyon
Published: 2023
PubMed ID: 37954397
Study type:

combined biological and clinical study
Data availability: GSE147597; GSE147602; GSE147603; GSE147711
Code availability: -