circRNA basic information
circBase ID: hsa_circ_0001513
Name: hsa_circ_LNPEP
Synonym: -
Host Gene: LNPEP
Genomic location(hg19): chr5:96314841-96322374:+
Genomic location(hg38): chr5:96979137-96986670:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005081
MONDO name: preeclampsia
Disease details: preeclampsia / PE
Disease DO ID:
 10591
Disease MeSH ID:
 D011225
Disease NCIt ID:
 C85021
Disease ICD11 ID:
 229121159
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

placental tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HMGCS1, MAP1LC3B
Associated microRNA: hsa-miR-188-5p, hsa-miR-760
Biological function: May participate in PE pathology as a ceRNA that captures hsa-miR-188-5p and hsa-miR-760 and is linked to regulation of HMGCS1 and MAP1LC3B.
Molecular mechanism: ceRNA mechanism involving hsa-miR-188-5p/HMGCS1 and hsa-miR-760/MAP1LC3B axes
Biological pathway or process:

ceRNA regulation (other); autophagy (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001513 was down-regulated in PE placental tissue and its expression pattern was consistent with RT-qPCR validation. The study proposed that it may function as a ceRNA involving hsa-miR-188-5p/HMGCS1 and hsa-miR-760/MAP1LC3B axes in PE.
Confidence score:

0.4032
Other information
Title:

Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.

Journal: Placenta
Published: 2022
PubMed ID: 35121166
Study type:

combined bioinformatics and clinical study
Data availability: GSE102897; GSE96984; GSE10588; GSE84260; GSE165324; Supplementary data: https://doi.org/10.1016/j.placenta.2022.01.013
Code availability: -