| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-24-3p |
| Biological function: |
Promotes proliferative, migratory, invasive and metastatic potentials of prostate cancer cells; high expression is linked to lymphatic metastasis and distant metastasis. |
| Molecular mechanism: |
circ_PRKCI functions through a miRNA sponge-like mechanism by binding and negatively regulating miR-24-3p, thereby triggering proliferative and metastatic potentials in prostate cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
High circ_PRKCI expression is associated with high risks of lymphatic metastasis and distant metastasis in PCa patients and may provide potential hallmarks for detection, treatment and monitoring of PCa. |
| Description: |
circ_PRKCI is up-regulated in prostate cancer tissues and cell lines. Its high expression is associated with lymphatic and distant metastasis, and functional knockdown experiments indicate that it promotes prostate cancer cell proliferation, migration and invasion. Mechanistically, circ_PRKCI binds and negatively regulates miR-24-3p, forming a circ_PRKCI/miR-24-3p axis that contributes to malignant PCa phenotypes. |
| Confidence score: |
0.6479 |