| Expression pattern: |
UP |
| Associated gene: |
FGF5, Ago2 |
| Associated microRNA: |
miR-1249-3p |
| Biological function: |
promotes NSCLC cell proliferation, migration, invasion and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0001715 acts as a miR-1249-3p sponge and upregulates FGF5 via targeting miR-1249-3p |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0001715 could be a potential target to promote the diagnosis and treatment of NSCLC |
| Description: |
circ_0001715 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and xenograft tumor progression while inhibiting apoptosis by sponging miR-1249-3p and increasing FGF5 expression. The study suggests circ_0001715 may serve as a potential diagnostic or therapeutic target in NSCLC. |
| Confidence score: |
0.8175 |