| Expression pattern: |
UP |
| Associated gene: |
TGFbetaR1, TGFBR1, P-Smad2/3, Smad2/3 |
| Associated microRNA: |
miR-202-5p |
| Biological function: |
Promotes ESCC cell proliferation, migration, invasion, tumor growth and metastasis; functions as an oncogenic RNA and potential tumor marker. |
| Molecular mechanism: |
circ_0006156 acts as a ceRNA/endogenous sponge for miR-202-5p, relieving suppression of TGFbetaR1 and activating the TGFbeta/Smad pathway. |
| Biological pathway or process: |
TGF-beta/SMAD (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0006156 expression is associated with shorter overall survival and is an independent risk factor for OS; it may serve as a potential tumor marker and biomarker for diagnosing ESCC. |
| Description: |
circ_0006156 (hsa_circ_0006156) is up-regulated in ESCC tissues and cell lines and high expression predicts poorer overall survival. Functionally, it promotes ESCC proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, cytoplasmic circ_0006156 sponges miR-202-5p, relieves repression of TGFbetaR1, and activates TGFbeta/Smad signaling. |
| Confidence score: |
0.8862 |