| Expression pattern: |
UP |
| Associated gene: |
MYLIP |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration, and invasion, and inhibits apoptosis; silencing circ-RANGAP1 suppresses OS cell progression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-542-3p, thereby regulating MYLIP (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down |
| Clinical significance: |
Higher circ-RANGAP1 expression indicated a poor prognosis in OS patients; associated with poor clinicopathology. |
| Description: |
circ-RANGAP1 is up-regulated in osteosarcoma tissues/cells and its high expression is associated with poorer clinicopathological features and overall survival. Functionally, circ-RANGAP1 promotes OS cell proliferation, migration, and invasion and inhibits apoptosis by sponging miR-542-3p to regulate MYLIP. |
| Confidence score: |
0.7321 |