| Expression pattern: |
UP |
| Associated gene: |
MMP16, CyclinD1, N-cadherin |
| Associated microRNA: |
miR-139-5p |
| Biological function: |
circ_0013290 promotes HCC cell malignancy, including cell viability, proliferation, invasion, tube formation and tumor tumorigenesis, and inhibits apoptosis; Matrine suppresses HCC malignancy partly by downregulating circ_0013290. |
| Molecular mechanism: |
circ_0013290 acts as a miR-139-5p sponge to regulate MMP16 expression; Matrine inhibits HCC progression by decreasing circ_0013290 and subsequently affecting the miR-139-5p/MMP16 pathway. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); angiogenesis (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0013290 is up-regulated in HCC tissues and cell lines and functions as a cancer-promoting circRNA. It sponges miR-139-5p to increase MMP16 expression, thereby promoting HCC cell proliferation, invasion, tube formation and tumorigenesis while suppressing apoptosis. Matrine exerts anti-HCC effects by downregulating circ_0013290 and modulating the circ_0013290/miR-139-5p/MMP16 pathway. |
| Confidence score: |
0.8006 |