| Expression pattern: |
UP |
| Associated gene: |
RGS17 / RGS17 mRNA / Ago2 |
| Associated microRNA: |
miR-203-3p |
| Biological function: |
Promotes NSCLC cell growth, proliferation, migration, and invasion; plays a cancer-promoting role in NSCLC development. |
| Molecular mechanism: |
circ_0006220 functions as a miR-203-3p sponge and positively regulates RGS17 expression through the circ_0006220/miR-203-3p/RGS17 ceRNA axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot |
| Clinical significance: |
High circ_0006220 expression was associated with increased tumor size, advanced TNM stage, unfavorable clinicopathological indicators, and was proposed as a diagnostic biomarker and therapeutic target for NSCLC. |
| Description: |
circ_0006220 is up-regulated in NSCLC tissues and cell lines and is associated with unfavorable clinicopathological features. Functionally, it promotes NSCLC cell growth, proliferation, migration, and invasion. Mechanistically, circ_0006220 acts as a cytoplasmic miR-203-3p sponge to increase RGS17 expression through a circ_0006220/miR-203-3p/RGS17 ceRNA axis. |
| Confidence score: |
0.7404 |