| Expression pattern: |
DN |
| Associated gene: |
ZNRF3, Ago2, PCNA, MMP9 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
Suppresses GC cell proliferation, migration, invasion and xenograft tumor growth; promotes ferroptosis, apoptosis and cell death; low expression is associated with advanced TNM stage and low survival rate. |
| Molecular mechanism: |
Circ_0000190 acts as a miRNA sponge for miR-382-5p and positively regulates ZNRF3, thereby suppressing proliferation and motility and inducing ferroptosis in GC cells. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ferroptosis (promotes); apoptosis (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low expression of circ_0000190 is associated with advanced TNM stage and low survival rate of GC patients, and may be a poor prognostic indicator. |
| Description: |
Circ_0000190 is down-regulated in gastric cancer tissues and cell lines, and low expression is associated with advanced TNM stage and worse survival. Functionally, circ_0000190 suppresses proliferation, migration, invasion and xenograft tumor growth while promoting ferroptosis and apoptosis. Mechanistically, it sponges miR-382-5p to up-regulate ZNRF3 expression in GC cells. |
| Confidence score: |
0.8465 |