| Expression pattern: |
DN |
| Associated gene: |
RNF180 mRNA |
| Associated microRNA: |
hsa-miR-1301-3p |
| Biological function: |
Functions as a tumor suppressor; overexpression inhibits proliferation, colony formation, migration and invasion of HCC cells; associated with microvascular invasion and has diagnostic biomarker potential. |
| Molecular mechanism: |
Bioinformatically predicted circRNA-miRNA-mRNA interaction network involving hsa-miR-1301-3p; the specific mechanism remains to be elucidated. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circRNF180 expression was significantly associated with microvascular invasion; circRNF180 had diagnostic performance for distinguishing HCC tissues from normal tissues with AUC = 0.903. |
| Description: |
circRNF180 was significantly downregulated in HCC and was the main functional circRNA investigated in this study. Its overexpression suppressed HCC cell proliferation, colony formation, migration and invasion, and low expression was associated with microvascular invasion, supporting a tumor-suppressive and biomarker role. |
| Confidence score: |
0.7907 |