| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-18b-5p |
| Biological function: |
Exosomal circ-FBXW7 enhances oxaliplatin sensitivity, promotes oxaliplatin-induced apoptosis, inhibits oxaliplatin-induced epithelial-mesenchymal transition, suppresses oxaliplatin efflux, and inhibits migration and invasion in oxaliplatin-resistant CRC cells. |
| Molecular mechanism: |
Exosome-mediated transfer of circ-FBXW7 ameliorates oxaliplatin chemoresistance in CRC by directly binding to and sponging miR-18b-5p. |
| Biological pathway or process: |
chemoresistance (inhibits); drug resistance (inhibits); apoptosis (promotes); EMT (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-FBXW7 was decreased in oxaliplatin-resistant CRC patients and cells, and exosome-transmitted circ-FBXW7 was proposed as a promising therapeutic strategy for oxaliplatin-resistant CRC patients. |
| Description: |
circ-FBXW7 is down-regulated in oxaliplatin-resistant CRC patients and resistant CRC cells. Exosome-mediated delivery of circ-FBXW7 sensitizes resistant CRC cells and xenografts to oxaliplatin by sponging miR-18b-5p, promoting apoptosis and suppressing EMT, motility, drug efflux, and chemoresistance. |
| Confidence score: |
0.7045 |