| Expression pattern: |
UP |
| Associated gene: |
AGO2, KCCN3 |
| Associated microRNA: |
miR-29a-5p, miR-141-3p, miR-499a-3p, miR-570-5p, miR-26a-5p |
| Biological function: |
Promotes proliferation, migration, and invasion of keloid dermal fibroblasts; promotes keloid progression. |
| Molecular mechanism: |
Acts as a cytoplasmic miRNA sponge; directly binds miR-29a-5p; associates with AGO2 in RISC; proposed miR-29a-5p/KCCN3 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
Identified as a biomarker and potential therapeutic target for keloids. |
| Description: |
hsa_circ_0006867 is up-regulated in keloid dermal fibroblasts and promotes fibroblast proliferation, migration, and invasion in vitro. It mainly localizes to the cytoplasm and functions as a miRNA sponge, with experimental support for binding miR-29a-5p and association with AGO2, suggesting a potential miR-29a-5p/KCCN3 regulatory axis in keloid progression. |
| Confidence score: |
0.7372 |