| Expression pattern: |
UP |
| Associated gene: |
Ago2, HIF1A, c-myc, cyclin D1, bcl-2, GLUT1, LDHA |
| Associated microRNA: |
miR-541-5p |
| Biological function: |
circRTN4IP1 promotes ICC cell proliferation, cell cycle progression, glucose metabolism/glycolysis and tumor formation, while inhibiting apoptosis. |
| Molecular mechanism: |
circRTN4IP1 functions as a ceRNA by sponging miR-541-5p to relieve repression of HIF1A, thereby promoting ICC malignant progression and glucose metabolism. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); glycolysis (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
circRTN4IP1 is a possible therapeutic target for ICC. |
| Description: |
circRTN4IP1 is up-regulated in ICC tissues and cell lines and functions as an oncogenic circRNA. It promotes ICC cell proliferation, cell cycle progression, glycolytic glucose metabolism and xenograft tumor growth while suppressing apoptosis. Mechanistically, circRTN4IP1 sponges miR-541-5p to increase HIF1A expression, suggesting the circRTN4IP1/miR-541-5p/HIF1A axis as a potential therapeutic target in ICC. |
| Confidence score: |
0.8568 |