| Expression pattern: |
UP |
| Associated gene: |
MDM4 |
| Associated microRNA: |
miR-183-5p |
| Biological function: |
Promotes glioma cell growth/proliferation, migration and invasion; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a cytoplasmic ceRNA sponge for miR-183-5p to elevate MDM4 expression at the posttranscriptional level. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High expression of circ_0079586 correlates with advanced WHO grade, tumor size, and unfavorable prognosis/poor overall survival in glioma patients. |
| Description: |
circ_0079586 is up-regulated in glioma tissues and cell lines and is associated with more severe clinicopathological features and poorer overall survival. Functionally, it promotes proliferation/growth, migration and invasion while inhibiting apoptosis, mainly by acting as a cytoplasmic miR-183-5p sponge to increase MDM4 expression. |
| Confidence score: |
0.7369 |