| Expression pattern: |
DN |
| Associated gene: |
E2F2 |
| Associated microRNA: |
miR-214-5p |
| Biological function: |
CircCUL2 suppresses proliferation, invasion and migration of retinoblastoma cells. |
| Molecular mechanism: |
CircCUL2 negatively regulates miR-214-5p, and miR-214-5p negatively regulates E2F2; circCUL2 inhibits retinoblastoma cell proliferation, invasion and migration through the miR-214-5p/E2F2 axis. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); migration (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
The main finding may provide a therapeutic strategy for patients with retinoblastoma. |
| Description: |
CircCUL2 is down-regulated in retinoblastoma tissues and cell lines. Functionally, circCUL2 suppresses retinoblastoma cell proliferation, invasion and migration by negatively regulating miR-214-5p and relieving miR-214-5p-mediated repression of E2F2, suggesting potential therapeutic relevance. |
| Confidence score: |
0.6521 |