circRNA basic information
circBase ID: -
Name: hsa_circ_SEPT9
Synonym: circSEPT9
Host Gene: SEPT9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005595
MONDO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma / LSCC
Disease DO ID:
 2876
Disease MeSH ID:
 -
Disease NCIt ID:
 C4044
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; noncancer tissues; paired LSCC and nontumor tissues
Cell lines:

UM-SCC-17A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: miR-10a gene
Associated microRNA: miR-10a
Biological function: circSEPT9 promotes LSCC cell proliferation and may play oncogenic roles.
Molecular mechanism: circSEPT9 increases methylation of the miR-10a gene, downregulates miR-10a expression, and thereby increases LSCC cell proliferation.
Biological pathway or process:

proliferation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; MSP (Methylation-Specific PCR); Transfection; CCK8
Clinical significance:

-
Description:

circSEPT9 is up-regulated in LSCC tissues and functions as an oncogenic circRNA in this study. It promotes UM-SCC-17A cell proliferation by increasing methylation of the miR-10a gene and reducing miR-10a expression.
Confidence score:

0.5812
Other information
Title:

CircRNA circSEPT9 Downregulates miR-10a through Methylation to Promote Cell Proliferation in Laryngeal Squamous Cell Carcinoma.

Journal: Critical reviews in eukaryotic gene expression
Published: 2021
PubMed ID: 34936289
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available because it contains information that could compromise the privacy of research participants.
Code availability: -