| Expression pattern: |
DN |
| Associated gene: |
RNF8, AR (androgen receptor) |
| Associated microRNA: |
hsa-miR-3619-5p, hsa-miR-6781-5p, hsa-miR-128-1-5p, hsa-miR-4743-5p, hsa-miR-185-3p, hsa-miR-214-3p, hsa-miR-128-2-5p, hsa-miR-761, hsa-miR-6829-5p, hsa-miR-34a-5p |
| Biological function: |
May serve as a marker to differentiate prostate cancer from benign prostatic hyperplasia and could be a novel diagnostic marker and potential treatment target in PCa. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circ_0005692 may act as a miRNA sponge (e.g., miR-214-3p) to regulate downstream targets (e.g., RNF8). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Sanger Sequencing; Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0005692 was one of the markers to differentiate prostate cancer from prostate hyperplasia, it may serve as a novel diagnostic marker and target for treatment of PCa patients. |
| Description: |
hsa_circ_0005692 is significantly down-regulated in prostate cancer tissues versus BPH and was validated by qRT-PCR (with Sanger confirmation of PCR product specificity). Bioinformatic prediction suggests it may act as a ceRNA/miRNA sponge (e.g., for miR-214-3p) and potentially regulate downstream targets such as RNF8, indicating potential diagnostic biomarker value in PCa. |
| Confidence score: |
0.5135 |