circRNA basic information
circBase ID: hsa_circ_0005785
Name: hsa_circ_ANAPC7
Synonym: circ-anaphase promoting complex subunit 7 (ANAPC7)
Host Gene: ANAPC7
Genomic location(hg19): chr12:110819556-110834257:-
Genomic location(hg38): chr12:110381751-110396452:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow specimens; bone marrow samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for AML diagnosis, disease condition monitoring, and supervising recurrence; expression correlates with white blood cell counts and blast percentage in bone marrow.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Circ-ANAPC7 has significant auxiliary diagnostic value for AML and may be used for disease monitoring and supervising recurrence; it was not related to OS and DFS.
Description:

This study validated that circ-ANAPC7 is up-regulated in AML bone marrow samples by RT-qPCR. Its expression has auxiliary diagnostic value, correlates with WBC count and bone marrow blast percentage, and changes with disease status, supporting its potential use for AML diagnosis and monitoring recurrence. The study did not establish a molecular mechanism or a prognostic survival association.
Confidence score:

0.4758
Other information
Title:

Using Circ-ANAPC7 as a Novel Type of Biomarker in the Monitoring of Acute Myeloid Leukemia.

Journal: Acta haematologica
Published: 2022
PubMed ID: 34879367
Study type:

clinical study
Data availability: All data generated or analyzed during this study are included in this article.
Code availability: -