| Expression pattern: |
DN |
| Associated gene: |
RUNX3, AGO2 |
| Associated microRNA: |
miR-558 |
| Biological function: |
Suppresses proliferation, migration and invasion of prostate cancer cells and inhibits tumor growth. |
| Molecular mechanism: |
Acts as a miR-558 sponge (ceRNA-like) to increase RUNX3 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model |
| Clinical significance: |
Potential biomarker for PCa. |
| Description: |
circTENM3 (hsa_circ_0071478), derived from TENM3, is down-regulated in prostate cancer. It mainly localizes in the cytoplasm and suppresses PCa cell proliferation, migration and invasion and inhibits tumor growth by sponging miR-558 to relieve repression of RUNX3. |
| Confidence score: |
0.7962 |