| Expression pattern: |
UP |
| Associated gene: |
WASF3 |
| Associated microRNA: |
hsa-miR-31, hsa-miR-767-3p, hsa-miR-935 |
| Biological function: |
promotes breast cancer progression; may increase invasive potential |
| Molecular mechanism: |
ceRNA mechanism: hsa-circ-0100153 sponges hsa-miR-31, hsa-miR-767-3p and hsa-miR-935 and is positively correlated with WASF3; associated with DNA replication and cell cycle functions in network analysis |
| Biological pathway or process: |
cell cycle (promotes); proliferation (promotes); invasion (promotes); metastasis (promotes); p53 signaling (other); ceRNA regulation (promotes) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Survival Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
High expression of hsa-circ-0100153 correlated with shorter overall survival; potential biomarker for cancer diagnosis and prognosis |
| Description: |
hsa-circ-0100153 is up-regulated in breast cancer and is positively correlated with WASF3 expression. Network-based analyses suggest it promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p and hsa-miR-935, and is linked to cell-cycle related functions. High hsa-circ-0100153 expression is associated with shorter overall survival. |
| Confidence score: |
0.459 |