| Expression pattern: |
UP |
| Associated gene: |
IGF1R |
| Associated microRNA: |
miR-107 |
| Biological function: |
circ_0005033 acts as an oncogenic circRNA in LSCC; its silencing suppresses cell viability, proliferation, migration, invasion, xenograft tumor growth and Cisplatin resistance, while promoting apoptosis. |
| Molecular mechanism: |
circ_0005033 functions through a ceRNA mechanism by targeting/sponging miR-107 and thereby regulating IGF1R expression; circ_0005033 knockdown activates death receptor-mediated and mitochondrial-regulated apoptotic pathways and reduces invasion/proliferation-associated proteins. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0005033 may provide a new indicator for distinguishing LSCC tumor from noncancerous tissues and might be a diagnostic and prognostic biomarker. |
| Description: |
In this study, hsa_circ_0005033/circ_0005033 was upregulated in LSCC tissues and cells and functioned as an oncogenic circRNA. Its knockdown inhibited LSCC cell viability, proliferation, migration, invasion, xenograft growth and Cisplatin resistance while promoting apoptosis. Mechanistically, circ_0005033 acted through a circ_0005033/miR-107/IGF1R ceRNA axis. |
| Confidence score: |
0.8298 |