| Expression pattern: |
UP |
| Associated gene: |
CDK16 |
| Associated microRNA: |
miR-584-5p |
| Biological function: |
Promotes HCC cell proliferation and tumour growth; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-584-5p to up-regulate CDK16. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Clinical Sample Validation |
| Clinical significance: |
Provided as a novel marker/target for HCC diagnosis and treatment. |
| Description: |
circ_1306 (circRNA 001306) is up-regulated in HCC tissues and cell lines and promotes proliferation and tumour growth while inhibiting apoptosis. Mechanistically, it sponges miR-584-5p to de-repress CDK16, forming a circ_1306/miR-584-5p/CDK16 axis with potential diagnostic/therapeutic relevance in HCC. |
| Confidence score: |
0.7954 |