| Expression pattern: |
UP |
| Associated gene: |
ZBTB20, CyclinD1, Bax, MMP9 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Circ-SFMBT2 facilitates AML cell proliferation, migration, invasion and glycolysis, and inhibits apoptosis. |
| Molecular mechanism: |
circ-SFMBT2 acts as a miR-582-3p sponge to up-regulate ZBTB20 expression, thereby promoting AML progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Circ-SFMBT2 might provide a promising therapeutic target for AML. |
| Description: |
Circ-SFMBT2 is up-regulated in AML patient serum and AML cell lines. Functionally, circ-SFMBT2 promotes AML cell proliferation, migration, invasion and glycolysis while suppressing apoptosis. Mechanistically, it acts as a miR-582-3p sponge to increase ZBTB20 expression, suggesting a potential therapeutic target in AML. |
| Confidence score: |
0.7416 |